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- Protein purification system PROPS series
- Product Detail
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- Protein purification system PROPS series
Main application fields：
Protein purification system is mainly used in biopharmaceutical fields such as monoclonal antibodies, recombinant proteins, vaccines, biological products, antibiotics, natural products and polysaccharides.
It is used for downstream process separation and purification of biological products.
Product advantages
Modular design, providing multiple configurations to meet the needs of special process flow
The high-precision double plunger infusion pump with a number of patented technologies ensures excellent separation reproducibility;
– the place where the whole system is in contact with the liquid is composed of biocompatible materials and meets the requirements of FDA, uspvi and other relevant regulations;
– dad full spectrum direct reading detector avoids the instability and high failure rate caused by the traditional mechanical switching detector;
– the fixed wavelength detector lamp is a long-life LED lamp, with a service life of more than 8000 hours, reducing the maintenance cost;
– patented UV detector flow cell, low dead volume, low peak expansion, and improved chromatographic resolution;
– high sensitivity online pH, conductivity, UV detector, low dead volume, low peak expansion, and improved chromatographic resolution;
– automatic components such as buffer selector valve, automatic sample injection valve and column position valve are centralized to improve the automation of purification;
– it has the functions of pre column, post column, differential pressure alarm and bubble sensor detection, which greatly protects the safety of the system and chromatographic column;
– the chromatography workstation software meets the requirements of fda21cfr, Part11 / GLP / GMP
| Model | PROPS 25 | PROPS 100 | PROPS150 | PROPS 300 |
| Velocity range | 0.001-25ml/min | 0.001-100ml/min | 0.001-150ml/min | 1-300ml/min |
| Velocity accuracy | ±1.2% | ±1.2% | ±1.2% | ±2% |
| Maximum withstand voltage | 27.5Mpa | 10Mpa | 5Mpa | 3.5Mpa |
mixer
Mixing principle: dynamic mixing
Volume of mixing tank: 0.6ml, 2ml, 5ml or 15ml
Gradient accuracy: ± 0.5% (condition: 5-95%, flow rate above 2% of full scale)
valve
Type diaphragm valve or selector valve
8 valve inlets (maximum)
Including: inlet valve, injection valve, column position valve and outlet valve
Inlet valve
Inleta: 1, 2 or 10
Inletb: 1, 2 or 10
Column position valve: single column position, 5 column position or 9 column position
Outlet valve: 1 or 9
UV detector
Detector type: LED fixed wavelength or dad full spectrum read only
Number of wavelengths: 1, 2, 4 or full band
Wavelength range:
DF1: 280260 or 254nm (other calls)
Dad402: 200-400nm, any two wavelengths output (software setting)
Dad604: 200-600nm, any four wavelengths output (software setting)
Dad604: 200-800nm, any four wavelengths output (software setting)
Circulation tank:
Optical path 2mm, 2ul dead volume
Optical path 5mm, 6ul dead volume
Optical path 10mm, 8ul dead volume
PH & conductivity detector ptc01
Read range:
0.001-999.999ms/cm (conductivity), 0-14 (PH)
Accuracy: conductivity: ± 0.02ms/cm or 2% (within 0.3 to 300ms / cm)
PH: ± 0.1ph (in the range of 2-12)
Maximum pressure
5MPa (conductivity) / 0.5MPa (PH)
Flow cell volume: 20ul
Temperature range: 0-100 degrees
Temperature accuracy: ± 0.5 (within 4-45 degrees)
Collector type: open type (frac-02), closed type (frac-02p), refrigeration type (frac-02c)
Collector frac-02
Collection rack: 2
Maximum collection number: 384 (4 96 well plates)
Collection rack type: 1.5ml, 3ml, 5ml, 8ml, 15ml or 50ml
Collection volume: 0.1-50ml
Collector delay volume:
800ul (autopure100 standard, UV flow cell - collection end),
420ul (autopure25 standard, UV flow cell - collection end),
*The delay volume may change depending on the choice of configuration.
Bubble sensor:
Principle: ultrasonic, non-contact detection
Maximum quantity: 3, sample injection test, pump a test, pump B test or customized
Optional configuration
| AirS01-H | Bubble sensor for monitoring sample loading |
| CPV02RX | Column position valve, supporting forward / reverse / bypass |
| CPV03RX | 3 column position valve, supporting forward / reverse / bypass |
| CPV03RX*2 | 6 column position valve, supporting forward / reverse / bypass |
| MSV04 | Mobile phase selection module, 4 channels |
| MSV10 | Mobile phase selection module, 10 channels |
| DAD-UV | 260nm or 280nm fixed wavelength 260nm and 280nm fixed dual wavelength 200-400nm arbitrary dual wavelength |
| DAD604 | 200-600 nm, Dad detector, four channels |
| DAD804 | 200-800nm, Dad detector, four channels |
| pH detector | PH detector, 0-14 (best for ph2-12), temperature compensation, dead volume of flow cell: 88ul |
| OV02 | Outlet valve (large volume collection valve), 1 collection channels, 1 waste liquid. |
| OV10 | Outlet valve (large volume collection valve), 9 collection channels, 1 waste liquid. |
| SP25/100/300 | Sample pump sSP25/100/300 0.01-25ml/min， Velocity accuracy: 1.2%/1.2%/1.5% Maximum pressure 27.5mpa/10Mpa/3.5Mpa |
| SIV-09 | Sample inlet valve, 10 channels 9 sample inlets and 1 buffer inlet |
| PCP02 | Column front and column rear pressure monitoring module |
| PCP01 | Pre column pressure monitoring module |
| Frac-02 | Component collector, supporting 2 collection racks 1. 3 x 7, 30mm, 21 pipes, 2 Nos 2. 5 x 12, 16mm, 60 tubes, 2 Nos 3、6 × 15, 13mm, 90 pipe, 2 4. 96 hole plate, 4 |
| Frac-02P | Closed design to avoid sample contamination Component collector, supporting 2 collection racks 1. 3 x 7, 30mm, 21 pipes, 2 Nos 2. 5 x 12, 16mm, 60 tubes, 2 Nos 3、6 × 15, 13mm, 90 pipe, 2 4. 96 hole plate, 4 |
| Frac-02C | Closed design to avoid sample contamination Independent refrigeration temperature control, temperature control range 4-20 ° C, error ± 1.5 ℃ Component collector, supporting 2 collection racks 1. 3 x 7, 30mm, 21 pipes, 2 Nos 2. 5 x 12, 16mm, 60 tubes, 2 Nos 3、6 × 15, 13mm, 90 pipe, 2 4. 96 hole plate, 4 |
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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