Refeyn’s TwoMP The mass photometer,Refeyn Ltd._specification/price/image

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For molecular mass measurements with unmatched sensitivity, speed and simplicity of use. Refeyn’s second-generation mass photometer, the TwoMP, offers wider mass range, and improved resolution and statistics.

Mass photometry is a recent addition to the bioanalytical toolkit. By directly measuring molecular mass in solution, it reports on fundamental properties of the sample while a native environment is maintained. It is thus applicable to a wide range of different molecules and to both basic research and drug discovery.

Mass photometry measures mass at the single molecule level, providing insights into the composition and function of even complex samples and molecular mechanisms. This unique technology can detect and characterise proteins, nucleic acids, lipids and sugars. It provides information on structure (oligomeric state, modification), homogeneity, and function (quantifying interactions) – all in a matter of minutes and using tiny amounts of sample.

Due to its unique benefits, mass photometry addresses a major unmet need for more efficient analytical tools. It will ultimately help accelerate science, and the discovery and development of new therapeutics.

Key advances of the

Two^MP

Incorporating customer feedback, the latest advances in optics technology and custom software developments, Refeyn has evolved mass photometry to a new level with the next-generation mass photometer, TwoMP.

Wider mass range

Figure 1 Mass photometry with the Refeyn TwoMP allows mass measurements down to 30 kDa and features improved peak resolution at the detection limits.

The Refeyn TwoMP enables measurement of molecular mass across a wide mass range, from 30 kDa up to 5 MDa.

You can reliably measure molecular masses down to 30 kDa and better quantify molecules close to the detection limits.

Figure 1 shows mass photometry peak resolution on a 30 kDa protein. The mass photometry analysis with the TwoMP clearly distinguishes two peaks, corresponding to the monomers and dimers formed by the example protein in solution.

Mass photometry in action

Mass photometry measures mass at the single molecule level, providing insights into the composition and function of even complex samples and molecular mechanisms. This unique technology can be used to detect and characterise proteins, nucleic acids, lipids and / or sugars, providing information on structure (oligomeric state, modification), homogeneity, and function (quantifying interactions) – all in a matter of minutes, and using tiny amounts of sample.

Refeyn Ltd. specialises in the development, production, and distribution of mass photometry technology for industry and academia. Mass photometry is a unique bioanalytical technology pioneered by Refeyn that enables the measurement of molecular mass at the single-particle level by quantifying light scattering from biomolecules in solution. Spun out of Oxford University in 2018, the company aims to make mass photometry accessible to all in the scientific community, enabling users to achieve new and better outcomes. Refeyn has been recognised for its unique approach to biomolecular analysis through multiple awards, including the Royal Society of Chemistry Emerging Technologies Competition. Applications of mass photometry include: sample characterisation and analysis of protein oligomerisation, biomolecular interactions, and macromolecular assemblies. Utilising the novel technology of mass photometry, Refeyn’s products are capable of accurate mass measurement of single molecules in solution, in their native state, and without the need for labels, opening up new possibilities for bioanalytic and research into biomolecular function.