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Automated mass photometry

Automated mass photometry combines the ease and efficiency of automation with the unmatched sensitivity and simplicity of Refeyn’s molecular mass measurement technology. The automated mass photometer frees up operator time and offers enhanced precision, enabling rapid measurement of multiple samples with low sample consumption. Automation is compatible with both the OneMP and the Two^MP.

Highly reproducible results

Figure 1 Automated mass photometry measurements are highly reproducible. Autonomously run mass photometry measurements show (A) the mass distributions of IgG forming monomers and dimers (inset: mass histograms for each well). The measured mass (B) and total counts (C) across the wells show low variability.

The liquid-handling robot autonomously analyses 14 samples in 1 hour in a highly reproducible manner.

A straightforward, repeated measurement of a sample containing the antibody IgG illustrates the precision of the automated mass photometer, which is reflected in the high degree of reproducibility of the resulting data (Fig. 1).

Figure 1A shows histograms of 12 repeated measurements of an IgG sample made using automated mass photometry. Across the wells that contain the sample, the measured mass (Fig. 1B) and total counts (Fig. 1C) show low variability.

Refeyn Ltd. specialises in the development, production, and distribution of mass photometry technology for industry and academia. Mass photometry is a unique bioanalytical technology pioneered by Refeyn that enables the measurement of molecular mass at the single-particle level by quantifying light scattering from biomolecules in solution. Spun out of Oxford University in 2018, the company aims to make mass photometry accessible to all in the scientific community, enabling users to achieve new and better outcomes. Refeyn has been recognised for its unique approach to biomolecular analysis through multiple awards, including the Royal Society of Chemistry Emerging Technologies Competition. Applications of mass photometry include: sample characterisation and analysis of protein oligomerisation, biomolecular interactions, and macromolecular assemblies. Utilising the novel technology of mass photometry, Refeyn’s products are capable of accurate mass measurement of single molecules in solution, in their native state, and without the need for labels, opening up new possibilities for bioanalytic and research into biomolecular function.