Membrane proteins play critical roles in a wide range of cellular functions. The attachment of proteins to biological membranes has shown to regulate cell signaling and many other important cellular events through a variety of mechanisms. In vivo interactions with membrane lipids help stabilize the structure of these proteins, and promote rearrangement, assembly, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity. Some cytosolic proteins are recruited to different cellular membranes via specific membrane-targeting structural domains. Besides, lipids are also the natural substrates of many important enzymes in key metabolic pathways. Therefore, it is of critical importance to understand the interactions between proteins and lipids.
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