COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in COL1A2, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen(COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for COL1A2.
The Abbkine Cleaved-COL1A2 (G1102) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen anddetects endogenous levels of fragment of activated COL1A2 protein resulting from cleavage adjacent to G1102. The antibody has been validaed in WB, ELISA and reacts with Human samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-Cleaved-COL1A2 (G1102) Polyclonal Antibody at https://www.abbkine.com/product/cleaved-col1a2-g1102-polyclonal-antibody-abp50035.
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