CTSD encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in CTSD play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
The Abbkine Cleaved-Cathepsin D LC (G65) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen anddetects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65. The antibody has been validaed in WB, ELISA and reacts with Human, Monkey samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-Cleaved-Cathepsin D LC (G65) Polyclonal Antibody at https://www.abbkine.com/product/cleaved-cathepsin-d-lc-g65-polyclonal-antibody-abp50028.
bio-equip.cn