Translational Research (PK) will be involved in the design and execution of in vivo PK/ADME studies and the evaluation of clinical pharmacokinetic data to support the development of Creative Animodel product candidates.Creative Animodel conducts typical PK study which involves administering a fixed amount of the drug (the dose) to the subject (various animals) and at various times post dose, samples of an easily accessible tissue (usually blood/plasma) are drawn and collected for analysis of the drug and its metabolite concentrations.
Creative Animodel conducts typical PK study which involves administering a fixed amount of the drug (the dose) to the subject (various animals) and at various times post dose, samples of an easily accessible tissue (usually blood/plasma) are drawn and collected for analysis of the drug and its metabolite concentrations.http://www.creative-animodel.com/PK-PD/Drug-Metabolism-and-Pharmacokinetic-Services.html
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Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemo-induced models using these tumor samples and cell lines.
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