ExPlain™
A data analysis system for understanding genomics, transcriptomics, proteomics and NGS data through functional classification, promoter analysis, and pathway analysis tools.
ExPlain™ is a unique data analysis system that combines promoter and pathway analysis tools. Using the power of TRANSFAC®’s transcription factor binding site derived positional weight matrices, ExPlain™ enables you to identify transcription factors affecting gene expression in your microarray and RNA-Seq experiments, as well as predict how they, in combination, can induce observed gene expression patterns. With PROTEOME™’s pathway data, you can take your analysis further and gain insight into the key upstream signaling regulators influencing the activity of these transcription factors.
Benefits
• Perform high throughput prediction of transcription factor binding sites
• Model how transcription factors act together to affect gene expression patterns observed in microarray and RNA-Seq experiments
• Understand the cause, not just the effect, of differential expression in response to drug treatment, disease state, environmental conditions, and more
• Identify potential therapeutic targets or biomarkers acting upstream of your differentially expressed gene set
Key Features
• Advanced data management options for processing and filtering your microarray, ChIP-Seq and RNA-Seq data
• Specialized algorithms for optimized transcription factor binding site prediction
• Positional weight matrix algorithms for superior accuracy
• Combined positional weight matrix and pattern matching algorithms for superior sensitivity
• Genetic algorithms for generating complex promoter models
• Discovery algorithms for identifying novel DNA motifs
• Specialized algorithms and tools for advanced network and pathway analysis
• Fully interlinked with TRANSFAC® and PROTEOME™ reports
Access Options
Online
An online subscription provides access to the ExPlain web interface. Online subscriptions are available at the concurrent user, academic / non-profit lab, and institution-wide level. The concurrent user and academic / non-profit lab subscription levels require IP plus username/password authentication. IP only authentication is optionally available for the institution-wide subscription level.
Installed
An installed subscription allows for local installation of the ExPlain relational database and web interface, allowing uploaded data and analysis results to be stored behind your institution’s firewall. Installed subscriptions are only available at the institution-wide level. MySQL and Oracle platforms are supported.
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