Multi-parallel Stainless steel Bioreactor
Introduction：
Multi-parallel Bioreactors system normally consists of 2-16 sets, which applicated for Multimodal comparison test of Microorganism culture fermentation, optimization of fermentation process parameters, and verification of production process and related species. It can save much time and labor cost.
With complete functions and high degree of automation, it can be widely used in medicine, food industry, biological and chemical industry, agriculture, brewing and other industries. The equipment design and manufacturing meet the requirements of GMP.
Equipment features:
1. In-situ sterilization, safe and reliable.
2. No traditional leakage risk;
3. Multiple reliable inoculation methods, flame inoculation and pressure differential inoculation are available;
4. Reasonable structural design, beautiful appearance;
Features of Controlling System
Multiple Control Function
Associated control: temperature, stirring speed, pH, dissolved oxygen, defoaming, airflow, tank pressure, feed amount and other direct parameters.
Remote monitoring: Suitable for smartphones, tablets, laptops and PC for instant remote monitoring.
Step control: Users can switch directly between manual control and step control and set at least 10-step control program for temperature, agitation, PH, DO and feeding.
Smart PID control
Temperature, stirring speed, Ph, DO and other parameters in the tank can be controlled by subsection curve setting according to the process requirements.
Temperature Control: Adopt PID automatic control mode; SS316L jacket base for electric heating and cold water for cooling.
Dissolved oxygen control: equipped with DO electrode and shielded conductor, DO is associated with stirring motor speed, feeding, airflow, tank pressure and other parameters.
PH value control: Intelligent PID system control built-in control peristaltic pumps for acid-alkali adjustment, with high control precision.
Antifoam control: Foams are automatically detected and the peristaltic pump is controlled to add defoamer in proportion to time.
Feeding control: Peristaltic pump switch control (manual, automatic, and off); accumulation volume control; coupled with other parameters (DO, pH, etc).
Upgrading option list
Gas mixing options: Air/O2/CO2/N2
Cleanliness detection
Online live cell detectio
Automatic vessel pressure control
Top areation
Thermal mass flow controller
CO2 detection
Redox
Exhaust detection analysis
Liquid level
Filling weighing system
Methanol and ethanol content online detection
Additional feed pump
Variable speed pump
Upper controller
Magnetic drive
Customizable blade
Vessel passivation
Custom port
Cover lifting
Specification of Multi-parallel Stainless steel Bioreactor
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Parameter
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Description
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Total volume
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5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 5KL, 50KL etc.
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Working volume
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30%~70%
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Tank
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Jacket tank, made by SS316 and SS304, tank design pressure 0.3Mpa, jacket design pressure 0.35Mpa, polishing 0.4-0.6um, ratio of
diameter and height is 1:2.2-2.5
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Stirring system
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Mechanical drive on the top/bottom or Magnetic drive on the top, 3pcs height adjustable six-blade paddle
Stir speed: 50~1000rpm/50-400rpm
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Sterilization
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Sterilize in place(SIP), auto control by program
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Clean
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Clean in place (CIP) by spray ball
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Gas control
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Control by rotor meter, air flow 1 vvm
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Feeding
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Automatically feeding by peristaltic pump
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Anti-foam control
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Automatically add antifoam by peristaltic pump
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Temperature control
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Auto-control, electric heating range: water source add 5℃ to 70℃
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PH control
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PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland.
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Do control
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0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.
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Sampling
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Sampling valve, can sterilization separately, manual
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Harvest
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Zero dead zone bottom valve(Gemu/Burket,Germany), can sterilization separately, manual/auto
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Lid lift system
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30L-500L have lid lift system, 700-1000L have human hole.
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Pressure
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Auto control, BD Germany pressure transmitter
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Exhaust
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Have condenser before exhaust, control by diagram valve / Proportional control valve.
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Control parameters
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10 or 15 inch touch screen , Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data
analysis, data record, data output, language(RU/EN/CN) and other customized functions
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Optional configuration
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Remote control, Mass flow meter(auto control gas), O2/N2/CO2, gas flow 2vvm, gas(CO2) exhaust analysis, Level sensor,
Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor(Biomass), Printing, Siemens touch screen, Double mechanical seal
, 4-Valves-group for feeding, Bottom valve auto discharge, ASME certificate, CSA certificate, Batch culture, Seed transfer, etc.
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