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- BioCAM DupleX
- Product Detail
- Company Profile
Introducing a fully bi-directional microelectrode array platform for 2D and 3D invitro imaging
In vitro electrophysiology reimagined
BioCAM DupleX is a state-of-the-art, high-resolution microelectrode array (also known as multielectrode array) platform for powerful in vitro functional imaging.
Its bidirectional electrodes make it possible to simultaneously record high-density electrophysiological data at 20 kHz and induce electrical neural network stimulation from any of the 4,096 microelectrodes.
This advanced platform works with both classical planar 2D cell culture as well as our innovative 3D HD-MEA technology.
The BioCAM DupleX is compatible with our latest generation of Khíron chips, which feature 4,096 µNeedle electrodes to penetrate structured brain tissues and obtain signals from inside your biological models such as slices, organoids, or spheroids.
1 product, 15 years of R&D
BioCAM DupleX is the result of 15 years of research and development, embodying our experience in bioengineering CMOS microelectrode array (MEA) devices, electrophysiology, data processing and biological models.
It is electrophysiology at its best.
BioCAM Idea
2004
BioCAM 4096
2012
BioCAM X
2015
BioCAM DupleX
2019
An ideal match: BioCAM DupleX and Khíron
The BioCAM DupleX is the first Microelectrode Array platform of its kind able to power 3D high-density CMOS-MEA chips.
Complex electrophysiology setups, where the wiring of a single electrode to the amplifier can significantly change the noise level and impair the experiment, or where the interpretation of the signals coming from your setup is restricted to electrophysiological experts, are now a distant memory.
BioCAM DupleX makes setup as easy as possible by automating important settings and optimizing noise, thus making electrophysiology accessible to everyone. Complex electrophysiological traces are then converted into microscopy-like, easy-to-understand, fast-to-process functional images.
Bidirectional platform
Whenpaired with the HD-MEA from the Khíron family (Accura HD-MEA), the BioCAM DupleX can use any of the recording sites to release an electrical stimulus, thus making it a fully bidirectional platform.
Coupled with BrainWave, our unique integrated software for recording, stimulation and real-time processing, BioCAM DupleX is the perfect solution for easily setting up complex experiments. Study functional connectivity, information processing or complex behaviors like learning and memory in neuronal networks – all without the need for external stimulating electrodes or third-party electronics.
Precision at your fingertips
After inserting a microelectrode array (HD-MEA) chip into the BioCAM DupleX, the motorized locking mechanism activates with a simple press of the lock button to enable precise contact and alignment. The system automatically recognizes the MEA chip and is ready to acquire data.
A convenient set of LED lights shows whenthe BioCAM DupleX is powered on, whether the MEA chip is locked in and when the system is recording.
Integrated reference
The BioCAM DupleX features an integrated reference electrode for the microelectrode array (MEA) chip to simplify the experimental procedure, reducing the risk of contamination, interference noise and accidental spills of media.
Hover on the BioCAM DupleX to discover more.
Advanced FPGA control to denoise, filter and compress high-density data
All surfaces around the MEA chip are magnetic for easy setup with other equipment, such as perfusion holders
Integrated heating and cooling system
4 independently programmable current stimulator channels
A motorized solution to reliably lockand unlock microelectrode array (MEA) chips
Crafted from aluminum to shield from electromagnetic and mechanical interference
Compact design for maximum impact
The BioCAM DupleX high-resolution microelectrode array (HD-MEA) platform is packed with features to enrich your research. At the same time, its small footprint makes for easy integration with instruments like microscope and perfusion or patch-clamp systems.
W 230 mm/9.5''
D 180 mm/7.08''
H 42 mm/1.65''
| Resources |
| Here you can find useful resources for your BioCAM DupleX |
| BioCAM DupleX Brochure |
| Tech specs |
| Main Controller |
| Computational core |
| Intel®'s Arria® 10 FPGA 13Gbps, 2GB DDR4, and ARM® dual-core Cortex™-A9 1.5 GHz |
| Data resolution |
| 12 bit |
| Number of simultaneous recording channels |
| 4096 |
| Sampling frequency (full-array) |
| 20 kHz/electrode |
| Region-of-interest |
| 1 - 4 independent subsets of electrodes (up to 64kHz sampling frequency) |
| Temperature control |
| Active heating and cooling system |
| Data interface |
| USB 3.1 Type-C |
| Ground reference |
| On-chip integrated |
| HD-MEA compatibility |
| Prime, Arena, Stimulo, Accura |
| 3D HD-MEA compatibility |
| Accura 3D (firmware upgrade required) |
| Control software compatibility |
| BrainWave 4 or higher |
| Inputs |
| Two analog inputs (-3.3 V to 3.3 V) or triggers (LV-TTL) |
| Stimulation Module |
| Integrated current stimulator |
| Yes |
| Real-time stimulation controller |
| Yes |
| Number of independent channels |
| 4 (2 int. and 2 ext.) |
| Internal (on-chip) stimulation sites |
| 4,096 (only with HD-MEA Accura) |
| External stimulation sites |
| 2 (accessible with optional connector box) |
| Maximum amplitude |
| +/- 1 mA |
| Amplitude resolution |
| 10 µA |
| Time resolution |
| 10 µs |
| Physical specs |
| Body material |
| Anodized aluminum and stainless steel |
| Locking mechanism |
| Motorized |
| Protection from liquid spill over |
| Anti spill barrier v. 2 |
| Dimensions (W x D x H) |
| 180 x 230 x 42 mm / 7.09 x 9.05 x 1.65 inches |
| Weight |
| 2 Kg / 4.4 pounds |
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3Brain is the world's first company to connect cells with sophisticated silicon chips in cell culture plates. The company has intensively worked on CMOS-powered cell-electronic interfaces with the aim of boosting research in major fields like neuroscience, ophthalmology and cardiology. After being the first to introduce CMOS-based HD-MEA (high-density microelectrode array), 3Brain is now setting up the next standard with the mentioned CorePlate? technology. 3Brain's goals continue by improving in vitro cell-based screening outputs and thus raising the potential of finding new treatments for brain diseases.
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