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- HyperCAM Alpha
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- HyperCAM Alpha
HyperCAM Alpha multi-well system: A new frontier in functional imaging
The 6-well CorePlate™-powered platform designed for both cell culture and tissue preparations
Your companion in functional cell screening
Thanks to the CorePlate™ MEA technology, HyperCAM Alpha delivers high resolution functional screening platform in a multi-well plate format.
The controlled environment allows label-free kinetic in vitro assays. The large sensing area of the per-well integrated microchip provides room for measuring either cell cultures, brain slices or brain organoids.
Alpha is equipped with the latest generation of FPGA accelerators to manage real-time high-resolution data from up to 13824 (2304 per well) simultaneously recorded electrodes.
Complex operations are handled by the sophisticated system so you can focus on measuring the functional properties of neurons.
Alpha accelerates your time-to-results without giving up any details
Parallelization does not have to be achieved at the cost of sacrificing data quality. Thanks to the 6-well CorePlate™ technology, Alpha provides thousands of electrodes per-well that can be arranged in different recording configurations to satisfy any experimental needs. The high statistical quality of the data generated by each well reduces the overall needs of replicates. While also giving access to single-cell details with a spatio- temporal resolution comparable to that provided by our single well HD-MEAs.
One system, multiple purposes
Regardless of whether you want to record human iPSC-derived neurons, dissociated murine cultures, acute brain and cardiac tissues, complex 3D neuronal assemblies, spheroids or brain organoids, HyperCAM Alpha is always your best choice.
Alpha leaves the freedom to operate with the chamber closed to provide incubator-like conditions for long term recordings as well as in an open configuration for acute measurement requiring the integration of fluidic systems. In both cases, optical access is guaranteed to always keep your preparations under control.
A concentration of high-tech solutions to simplify experimental procedures
HyperCAM Alpha is designed to reduce experimental hassles and allows you to fully concentrate on the most important thing: your assay.
The CorePlate™ multiwell’s environment is regulated by accurately controlling the temperature, CO₂ saturation and humidity through the software or even the integrated touchscreen.
The incubation chamber is water-proof to protect instrument electronics from accidental spill-out or experimental misuse.
The combination with the latest BrainWave software allows to easily visualize and analyze data from CorePlate™ devices.
Here you can find useful resources for your HyperCAM Alpha
HyperCAM Alpha BrochureComputational core
Intel®’s Arria® 10 FPGA 13Gbps, 2GB DDR4,
and ARM® dual-core Cortex™-A9 1.5 GHz
Data resolution
14 bit
Compatible with
6-well CorePlate™ technology
Number of simultaneous recording channels
13824 (2304 per well) @10kHz
or 6144 (1024 per well) @20kHz
Environmental chamber
With controlled temperature and CO2
concentration (via integrated air mixer)
and with monitored humidity
Touch screen
100k dots to read and set status of
environmental chamber values and
perform basic operations
(e.g., read/set temperature and
CO2, read RH%, lock/unlock the
CorePlate™ device, etc.)
Data interface
USB 3.1 Type-C data interface
Control software compatibility
BrainWave 5 or higher
| Stimulation Module |
| Integrated current stimulator |
| Yes |
| Number of independent channels |
| 2 |
| Stimulation sites |
| 24'576 (4'096 per well) |
| Maximum amplitude |
| +/- 1 mA |
| Amplitude resolution |
| 10 µA |
| Time resolution |
| 10 µs |
| Physical specs |
| Body material |
| Plastic |
| Chamber lid |
| Movable lid with transparent window that can be operated either by the software or manually |
| Locking mechanism |
| Motorized CorePlate™ locking system |
| Protection from liquid spill over |
| Chamber protected against dripping water |
| Dimensions (W x D x H) |
| 417 x 248 x 154 mm |
| Weight |
| 8.5 Kg / 18.7 pounds |
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3Brain is the world's first company to connect cells with sophisticated silicon chips in cell culture plates. The company has intensively worked on CMOS-powered cell-electronic interfaces with the aim of boosting research in major fields like neuroscience, ophthalmology and cardiology. After being the first to introduce CMOS-based HD-MEA (high-density microelectrode array), 3Brain is now setting up the next standard with the mentioned CorePlate? technology. 3Brain's goals continue by improving in vitro cell-based screening outputs and thus raising the potential of finding new treatments for brain diseases.
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