◆ Real-Time Imaging
◆ High Spacial Resolution
◆ Large View
◆ Non-contact
◆ Non-destructive

Introduction:

The SIM Blood Flow Imager has offered a real-time method for acquiring and record-ing the blood perfusion images, which is a key way to learn the pathological or physio-logical parameters of issue or organs for life science basic research and clinic research. SIM BFI imager has the specific advantages of non-contact, real-time imaging, high spa-cial resolution, large view field and no con-trast agent, which is based on the latest tech-nology of LASER SPECKLE CONTRAST IMAGING. The spacial resolution of the blood flow imaging could be up to millisec-ond level, and the temporal resolution could be up to micrometer level. By using SIM BFI imager, the distribution of the micro blood vessels and the relative change of the blood flow value can be observed and ana-lyzed, which is significant for doctors or re-searchers.

Features OF SIM Blood Flow Imager

High tem-poral/spacial resolution; high contrast;

Full field; no scan;

Non-contact ; No contast agent;

Multi- out-puts:image, video, blood flow val-ue, vessel diameter.

Performance Advantages:

◆ Acquire the blood flow images in real time with micrometer resolution, and advance the accuracy of the blood flow value by correcting the interference of static scattering or multiscattering.
◆ Analyze the blood flow mean value of the region of interest(ROI) and vessel diameter value online or offline, and analyze the blood flow mean value and standard deviation of the time of interest(TOI) offline, moreover, any shape and quantity of ROIs could be drawn, and the position and size of any ROI could be adjusted freely.
◆ The blood flow imaging speed could be achieve 60 fps even though in the condition of maximum pixels.

◆ The optical magnification could be read directly without calculation.
◆ Multi-format could be chosen for recording, like raw data/.jpg/.bmp/.png /.avi and so on .
◆ When record images, you could choose to image continuously or with a specific interval.
◆ An excellent system stabilization could be achieved based on high-coherence laser illuminating and high-performance 12-bit camera acquiring.
◆ A whole acquiring and analyzing plan and sale-service could be offered.

Application examples:

◆ Cortical blood flow imaging of tree shrew (nonhuman primate)
(a)Normal cortical blood flow distribution
(b) At the early time of over anesthesia
(c) At the end time of over anesthesia

◆ MACO Model
(a) Cerebral cortex blood flow maps of rats at different times after the preparation of MACO model, in which the red region indicated that the blood flow decreased to less than 20% of the normal value, the blue region indicated that the blood flow decreased to within 20-60% of the normal value, and the other regions indicated that the blood flow was still above 60% of the normal value; Collateral circulation was not observed in the severely ischemic cortex, but was observed in the normal cortex and the mildly ischemic area 15 minutes after the preparation of MCAO model.
(b) Relative change curve of blood flow in the labeled collateral circulation (CC1, CC2, CC3) during the whole monitoring process.

◆ Related research
(a) Photochemical ischemia
(b) Skin window
(c) Lower limbs of the rat
(d) Rat lower limb blood flow

Technique parameters:

◆ Laser Type:laser diode
◆ Laser Wavelength: 785nm
◆ Laser Control: constant current and constant temperature
◆ Image Size:2048*1536
◆ Working Distance: 200mm
◆ Magnification: 0.335-2.25*
◆ View Field: 6.31*4.71mm-42.2*31.6mm
◆ Spacial Resolution of Blood Perfusion Imaging: up to 3μm/pixel
◆ Temporal Resolution of Blood Perfusion Imaging: up to 60fps
◆ Analysis Parameters: blood perfusion value, blood diameter value, blood perfusion mean value of ROI, blood perfusion mean value and standard deviation of TOI
◆ ROI: any shape and quantity, position and size could be adjusted freely
◆ Record Mode: continuously or with specific intervals
◆ Record Formats: raw data, image like .jpg/.bmp/.png or video like .avi
◆ Software Function: register blood flow image and structural image, mark the special event during re-cording, record and load the analysis parameter, draw the grid for locating the object and so on.

Manufacturer: Shanghai Yuyan Instruments Co, Ltd.

Country of Origin:China

CONTACT INFORMATION

Shanghai Yuyan Instruments Co, Ltd.

Address: Room 506, XingMei Rd 485, Shanghai, 201100, China

Email:yuyanbio@vip.163.com