Continuous chromatographic separation of experimental equipment uses advanced design concepts and superb production process. It is suitable for a small amount of product preparation and process technology development, wide range of uses It is user-friendly and can be based on different product separation requirements flexible adjustment process.

Continuous chromatographic separation principle:

The chromatographic separation technique is based on the fact that different materials have different partition coefficients in the system consisting of stationary phase and mobile phase, and different retention times are presented in the mobile phase elution process to achieve separation. The traditional chromatographic

separation technique is carried out using a fixed chromatographic column. We first enter a certain amount of material, and then use eluent continuous elution. The same exit at different times can receive different product components, the process time and effort. After analysis and improvement, we made the stationary phase of the resin which can be continuous flow of the system. The separation of the material and the relative velocity of the stationary phase is achieved. Similar to the principles of the tortoise and the hare we put the fixed phase into a conveyor belt, the rabbit turtle, respectively, compared to the speed of the two different components. As long as the stationary phase adds a driving force in the opposite direction to the elution, so that the speed of the conveyor belt in the middle of the rabbit and turtle speed. Rabbits run faster than the fixed phase from the front, and the slow turtle was brought to the back of the conveyor belt.

We can use continuous moving bed system to achieve the above process:

Continuous chromatographic separation advantages:

l  Integration of all the steps can be continuous operation, the system matching is strong;

l  Significantly reduce the amount of resin, and give full play to the use of resin potential;

l  Extend the service life of the resin;

l  Reduce water and chemical consumption, and significantly reduce operating costs and reduce sewage emissions;

l  Remove or separate substances with different characteristics, which can be complex process simplification;

l  Maintain the stability of the product composition and concentration in the feed liquid;

l  Effectively improve the purity and concentration of product liquid, saving the cost of follow-up technology;

l  The use of multi-column system is flexible to change the production process;

l  Compact, small footprint, easy to install in any location;

l  Fully automated, programmed operation control, to ensure continuous and stable operation of the equipment; and

l  Flexibility to adjust the rotation speed or adjust the flow rate according to the process.

Typical applications:

l  Fructose separation production of crystalline fructose;

l  Separation and Purification of Xylitol and Arabinose;

l  Mannitol and sorbitol separation and purification;

l  Separation and purification of glucose and galactose;

l  Separation and purification of arabinose and ribose;

l  Glucose or maltose and high sugar separation and purification;

l  Maltose and glucose separation and purification;

l  Isolation of valine and alanine;

l  Soybean oligosaccharides in the raffinose, stachyose and monosaccharides, disaccharide separation;

l  Maltitol and oligosaccharides, sorbitol separation;

l  Citric acid chromatographic separation;

l  P-xylene adsorption separation;

l  Chiral compounds isolated; and

l  Separation of isomers.

Technical Parameters

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