CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells.
Human Poliovirus receptor (PVR) ELISA Kit employs a two-site sandwich ELISA to quantitate PVR in samples. An antibody specific for PVR has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPVR present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PVR is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PVR bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Poliovirus receptor (PVR) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/human-poliovirus-receptor-pvr-elisa-kit-kte61035/
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