ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail.The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Human Activin Receptor-Like Kinase 1 (ALK1) ELISA Kit employs a two-site sandwich ELISA to quantitate ACVRL1 in samples. An antibody specific for ACVRL1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyACVRL1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ACVRL1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ACVRL1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Activin Receptor-Like Kinase 1 (ALK1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/human-activin-receptor-like-kinase-1-alk1-elisa-kit-kte60905/
bio-equip.cn
中文
