Human Cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I) ELISA Kit,Abbkine_specification/price/image

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Type I collagen is a heterotrimer consisting of two α1(I) chains and one α2(I) chain. NTx assays are sensitive and specific assays that can be used to indicate subtle changes in levels of bone resorption. NTx serum and urine assays provide a quantitative measurement of the cross-linked N-telopeptides of bone type I collagen (NTx). NTx is a specific biochemical indicator of bone resorption that is generated as a result of osteoclast activity on bone. The NTx molecule is specific to bone due to the unique amino acid sequence and orientation of the cross-linked alpha-2 (I) N-telopeptide.NTx provides a dynamic indicator of the current level of bone resorption, shows significantly earlier response to therapy (with 3-6 months) and, when used in conjunction with bone mineral density (BMD), gives a more complete picture of bone status than either technology alone.

Human Cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I) ELISA Kit employs a two-site sandwich ELISA to quantitate CTX-I in samples. An antibody specific for CTX-I has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCTX-I present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CTX-I is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CTX-I bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/human-cross-linked-carboxy-terminal-telopeptide-of-type-i-collagen-ctx-i-elisa-kit-kte60831/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.