Neuroendocrine protein 7B2 is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme.Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Human Neuroendocrine protein 7B2 (SCG5) ELISA Kit employs a two-site sandwich ELISA to quantitate SCG5 in samples. An antibody specific for SCG5 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySCG5 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SCG5 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SCG5 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Neuroendocrine protein 7B2 (SCG5) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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