Human Amiloride-sensitive sodium channel subunit alpha (SCNN1A) ELISA Kit,Abbkine_specification/price/image

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Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Amiloride Sensitive Sodium Channel Subunit Alpha is the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.

Human Amiloride-sensitive sodium channel subunit alpha (SCNN1A) ELISA Kit employs a two-site sandwich ELISA to quantitate SCNN1A in samples. An antibody specific for SCNN1A has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySCNN1A present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SCNN1A is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SCNN1A bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Amiloride-sensitive sodium channel subunit alpha (SCNN1A) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/human-amiloride-sensitive-sodium-channel-subunit-alpha-scnn1a-elisa-kit-kte60737/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.