Syndecan 1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Human Syndecan-1/CD138 (SDC1) ELISA Kit employs a two-site sandwich ELISA to quantitate SDC1 in samples. An antibody specific for SDC1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySDC1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SDC1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SDC1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Syndecan-1/CD138 (SDC1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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