Human VPS10 domain-containing receptor SorCS3 (SORCS3) ELISA Kit,Abbkine_specification/price/image

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SORCS3 encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of SORCS3 in cell culture results in an increase in amyloid precursor protein processing.

Human VPS10 domain-containing receptor SorCS3 (SORCS3) ELISA Kit employs a two-site sandwich ELISA to quantitate SORCS3 in samples. An antibody specific for SORCS3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySORCS3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SORCS3 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SORCS3 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human VPS10 domain-containing receptor SorCS3 (SORCS3) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.