Syncollin is a 13 kDa protein that is highly expressed in the exocrine pancreas. Syncollin normally exists as a doughnut-shaped homo-oligomer (quite probably a hexamer) in close association with the luminal surface of the zymogen granule membrane.Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues.Syncollin is a small protein that is abundantly expressed in pancreatic acinar cells and that is tightly associated with the lumenal side of the zymogen granule membrane.
Human Syncollin (SYCN) ELISA Kit employs a two-site sandwich ELISA to quantitate SYCN in samples. An antibody specific for SYCN has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySYCN present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SYCN is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SYCN bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Syncollin (SYCN) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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