Human Signal transducer and activator of transcription 1 (STAT1) ELISA Kit,Abbkine_specification/price/image

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STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons.In response to IFN-gamma; stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.

Human Signal transducer and activator of transcription 1 (STAT1) ELISA Kit employs a two-site sandwich ELISA to quantitate STAT1 in samples. An antibody specific for STAT1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySTAT1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for STAT1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of STAT1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Signal transducer and activator of transcription 1 (STAT1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/human-signal-transducer-and-activator-of-transcription-1-stat1-elisa-kit-kte60375/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.