Tumor necrosis factor receptor superfamily member 14 is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism.The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.In melanocytic cells TNFRSF14 gene expression may be regulated by MITF.Widely expressed, with the highest expression in lung, spleen and thymus.
Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) ELISA Kit employs a two-site sandwich ELISA to quantitate TNFRSF14 in samples. An antibody specific for TNFRSF14 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTNFRSF14 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TNFRSF14 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TNFRSF14 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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