Triggering Receptor Expresses on Myeloid Cells-1 (TREM-1) belongs to the Ig superfamily that is expressed on myeloid cells. TREM-1 amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for TREM-1.
Human Triggering Receptor Expresses on Myeloid Cells-1 (TREM-1) ELISA Kit employs a two-site sandwich ELISA to quantitate TREM1 in samples. An antibody specific for TREM1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTREM1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TREM1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TREM1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Triggering Receptor Expresses on Myeloid Cells-1 (TREM-1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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