domain family 1 is a member of a family of leucine zipper containing transcription factors with repressor activity and belongs to the large family of early response genes. TSC-22 regulates cell growth and differentiation, and cell death. Leucine zipper structure of TSC22 inhibits the anchorage independent growth of cancer cells.TSC-22 is also an important downstream component of peroxisome proliferator-activated receptor (PPAR) and TGF-beta signaling during intestinal epithelial cell differentiation. TSC22 encodes a transcription factor and belongs to the large family of early response genes.TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.
Human Transforming growth factor-beta-stimulated Protein clone-22 (TSC22) ELISA Kit employs a two-site sandwich ELISA to quantitate TSC22D1 in samples. An antibody specific for TSC22D1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTSC22D1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TSC22D1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TSC22D1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Transforming growth factor-beta-stimulated Protein clone-22 (TSC22) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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