TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.Delta-Ef1 selectively transactivated the promoters of the SMC differentiation marker genes Acta2 and Myh11, and it physically interacted with Srf and Smad3, resulting in synergistic activation of the Acta2 promoter. Chromatin immunoprecipitation assays and knockdown experiments showed that delta-Ef1 was involved in control of SMC differentiation programs induced by Tgf-beta (TGFB1) signaling. Overexpression of delta-Ef1 inhibited neointima formation and promoted SMC differentiation.
Human Zinc finger E-box-binding homeobox 2 (ZEB2) ELISA Kit employs a two-site sandwich ELISA to quantitate ZEB2 in samples. An antibody specific for ZEB2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyZEB2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ZEB2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ZEB2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Zinc finger E-box-binding homeobox 2 (ZEB2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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