Transcription factor Maf (MAF) is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, Transcription factor Maf can be a transcriptional activator or repressor. Transcription factor Maf plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in MAF are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for MAF.
Bovine Transcription factor Maf (MAF) ELISA Kit employs a two-site sandwich ELISA to quantitate MAF in samples. An antibody specific for MAF has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyMAF present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MAF is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MAF bound in the initial step. The color development is stopped and the intensity of the color is measured.
Bovine Transcription factor Maf (MAF) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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