ARNT encodes aryl hydrocarbon receptor nuclear translocator containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. Aryl hydrocarbon receptor nuclear translocator binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. Aryl hydrocarbon receptor nuclear translocator is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
HIF-1β Polyclonal Antibody detects endogenous levels of HIF-1β protein.
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
HIF-1β Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/hif-1β-polyclonal-antibody-abp51514.
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