Insulin like growth factor 1 receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for IGF1R.
The Abbkine IGF-IR (phospho Tyr1161) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of IGF-IR protein only when phosphorylated at Y1161. The antibody has been validaed in WB, IHC-P, IP, ELISA and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-IGF-IR (phospho Tyr1161) Polyclonal Antibody at https://www.abbkine.com/product/igf-ir-phospho-tyr1161-polyclonal-antibody-abp50335.
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