Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 8 encoded by HDAC8 belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for HDAC8.
The Abbkine HDAC8 (phospho Ser39) Rabbit Polyclonal Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and detects endogenous levels of HDAC8 protein only when phosphorylated at S39. The antibody has been validaed in WB, IHC-P, ELISA and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Rabbit Anti-HDAC8 (phospho Ser39) Polyclonal Antibody at https://www.abbkine.com/product/hdac8-phospho-ser39-polyclonal-antibody-abp50326.
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