Primary mediastinal B-cell lymphoma (PMBCL) is a relatively rare lymphoma subtype affecting mainly young adults. Gene expression profile studies showed that it shares common features with classical Hodgkin lymphoma (cHL). Genetically, PMBCL has frequent copy number gains and translocation9 of the 9p24.1 locus resulting in PD-L1/PD-L2/JAK2 overexpression, genetic alterations and downregulation of CIIA and MHC-II suggesting immune evasion, and a mutational profile suggesting relatedness to classic HL. Recurrent mutations in PMBCL often affect the JAK/STAT and NF-κB pathways, in line with their constitutive activation. https://reagents.creative-diagnostics.com/research-area/primary-mediastinal-b-cell-lymphoma.html
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