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HE4 (Human Epididymis Protein 4)
HE4 (Human Epididymis Protein 4)
Place of Origin:
China
Brand:
Tellgen Corporation
Model:
Supplier:
Tellegn Corporation
Price:
Hits:
1506 
Updated:
10/28/2015
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    HE4 (Human Epididymis Protein 4) Compatible instrument: Luminex 200,TESMI F4000 . Reference Value: Females: < or =140 pmol/L Tellgen also provide following Tumor markers and Tumor Marker control : CA125 CA153 CA24-2 CYFRA21-1 AFP CEA CEA total PSA free PSA free-beta-hCG CA19-9 NSE SCCA CA72-4 CA50 HE4 ProGRP PGI/PGII Control 1 Control 2 Control 3 Increase in human epididymis protein 4 (HE4) suggests recurrence or disease progression, while a decrease suggests therapeutic response. A change in serum HE4 concentration of > or =20% is considered significant. Human epididymis protein 4 (HE4) belongs to the family of whey acidic four-disulfide core proteins. Currently, the biologic function of HE4 is unknown. HE4 has been shown to be overexpressed in 93% of serous, 100% of endometrioid, and 50% of clear cell ovarian carcinomas. In a study of 233 patients with a pelvic mass, including 67 with epithelial ovarian cancer, HE4 had a higher sensitivity for ovarian cancer detection than cancer antigen 125 (CA 125), 72.9% versus 43.3%, respectively, at a specificity of 95%. Researchers also found HE4 to be elevated in more than half of the ovarian cancer patients who did not have elevated CA 125 levels; therefore, the combination of markers provided slightly improved cancer diagnostic sensitivity for the detection of ovarian cancer. The main established application of HE4 is in post-therapy monitoring of ovarian cancer patients, who had elevated pretreatment levels. In this setting, it complements CA 125 measurement and facilitates follow-up of patients with little or no CA 125 pretreatment elevations. Certain histological types of ovarian cancer (mucinous or germ cell tumors) rarely express HE4, therefore the use of HE4 is not recommended for monitoring of patients with these types of ovarian cancer.
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    Shanghai Tellgen Corporation. was founded in 2003 and dedicated exclusively to the development, production and distribution of high-quality automated workflow solutions for research and clinical diagnostics laboratories in the life sciences sector. With the tremendous development, Tellgen became the the market leader in moleucular diagnosis area, and had consistently delivered series diagnostic products for healthcare
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