Technical Reports for Download
References
1.Unlocking the potential of the human genome with RNA interference. Hannon, G.J. and Rossi, J.J. Nature, 431, 371-378 (2004)
2.Mechanisms of gene silencing by double-stranded RNA. Meister, G. and Tuschl, T. Nature, 431, 343-349 (2004).
3.TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Chendrimada, T.P., Gregory, R.I., Kumaraswamy, E., Norman, J., Cooch, N., Nishikura, K. and Shiekhattar, R. Nature, 436, 740-744 (2005).
4.Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Kim, D.H., Behlke, M.A., Rose, S.D., Chang, M.S., Choi, S. and Rossi, J.J. Nat Biotechnol, 23, 222-226 (2005).
5.Functional polarity is introduced by Dicer processing of short substrate RNAs. Rose, S.D., Kim, D.H., Amarzguioui, M., Heidel, J.D., Collingwood, M.A., Davis, M.E., Rossi, J.J. and Behlke, M.A. Nucleic Acids Res, 33, 4140-4156 (2005).
6.siRNA function in RNAi: a chemical modification analysis. Chiu, Y.L. and Rana, T.M. RNA, 9, 1034-1048 (2003).
7.Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Harborth, J., Elbashir, S.M., Vandenburgh, K., Manninga, H., Scaringe, S.A., Weber, K. and Tuschl, T. Antisense Nucleic Acid Drug Dev, 13, 83-105 (2003).
8.Activation of the mammalian immune system by siRNAs. Marques, J.T. and Williams, B.R. Nat Biotechnol, 23, 1399-1405 (2005).
9.A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Marques, J.T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M.A. and Williams, B.R. Nat Biotechnol, 24, 559-565 (2006).
10.Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Judge, A.D., Bola, G., Lee, A.C. and MacLachlan, I. Mol Ther, 13, 494-505 (2006).
11.Progress towards in vivo use of siRNAs. Behlke, M.A. Mol Ther, 13, 644-670 (2006).
12.Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Amarzguioui, M., Lundberg, P., Cantin, E., Hagstrom, J.E., Behlke, M.A. and Rossi, J.J. Nature Protocols, 1, 508-517 (2006).
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