S-2238, which is specific to thrombin, is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by thrombin, it gives up a free pNA which could be detected by a spectrophotometer at 405 nm.
S-2238 is mainly used in anti-FIIa activity assay of heparin.
Applications:
S-2238 can be used in many applications, such as:
Anti-factor Xa activity to anti-factor IIa activity ratios of heparin and LMWHs
Anti-factor IIa activities of heparin and LMWHs
Activities of antithrombin and thrombin
Anti-factor IIa activities of heparin and LMWHs in human plasma
Production of kits for automated blood analyzers
Evaluation of potential anticoagulants from chemical synthesis, bacterial fermentation and animal tissues
Composition
S-2238 is white lyophizied powder, stored in vials.
Weight: 10mg and 25mg.
Each vial contains: S-2238 10 mg (15 μmol); mannitol 120 mg.
Physical and Chemical Properties:
Synonyms: S-2238, thrombin substrate
CAS number: 113711-77-6
Molecular formula: H-D-Phe-Pip-Arg-pNA-2HCl
Molecular weight: 625.6 Da
Purity: ≥ 99% (HPLC)
Absorption coefficient: A405nm ≤ 0.120 [L/(g·cm)]
Solubility: > 10 mg/mL (in pure water)
Usage
Reconstitute the entire contents of a vial, dissolve it with 5 mL distilled water to get a solution with concentration of 3 mmol/mL S-2238.
Stability and Storage:
The lyophilized powder of S-2238 could be preserved at 2 to 8 ℃ for at least 24 months.
The 3 mmol/mL S-2238 solution could be preserved at 2 to 8 ℃ for about 1 month.
Order Information:
Catalog number: AG00-0101
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