Overview

The Liberty Blue HT12 Automated Microwave Peptide Synthesizer is the gold standard for peptide synthesis. It features unmatched 4-minute cycle times along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. The HT12 upgrade for Liberty Blue allows for the fast sequential synthesis of up to 12 peptides which offers significant advantages over traditional parallel peptide synthesizers. This system is utilized in hundreds of laboratories worldwide and provides unparalleled peptide quality based on its unique methodology and use of microwave energy. The Liberty Blue HT12 features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance.

Awards

2014 R&D 100 Award Winner.

Unique Chemistry

CarboMAX™ coupling chemistry (patented)

Microwave deprotection and coupling (patented)

Features

4 min cycle time

90% waste reduction (HE-SPPS)

Automated sequential synthesis of up to 12 peptides

Flex-Add™ critical reagent delivery system (patented)

True Internal fiber-optic temperature control

0.005 - 5 mmol scale range

27 amino acid positions

Integrated Camera (optional)

HT12 Loader 

High-throughput peptide synthesis made easy.
Automated synthesize of up to 12 peptides (individual 20mer’s completed every 1.5 hours)
Liberty Blue HT12 sequential batch synthesis even keeps up with conventional parallel systems 

CarboMAX 

The best coupling method for peptide synthesis.
The fastest and most complete coupling
Stabilizes acid sensitive linkages which are problematic for standard carbodiimide chemistry (phospho, glyco, hyper-acid linkages)
Unmatched low-level of epimerization for all 20 amino acids due to faster activation (faster o-acylisourea formation)

FlexAdd 

The best way to deliver critical reagents.
Infinitely variable – deliver whatever volume you want (unlike sample loops)
No priming ever
No washing and less complex than syringe pumps
 

Solvent Reduction 
Unprecedented 90% solvent reduction.
Judicious use of solvents and reagents from optimized washing and synthetic protocols
Superior system design minimizes calibration, cleaning, and maintenance needs
 

Software 
The most advanced software for simple and flexible control.
Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
21 CFR Part 11 compliance including full run history and method reports
Integrated real-time camera into microwave cavity
 

Applications 

Synthesize standard and complex peptides.
Branched Peptides
Cyclized Peptides
Disulfide Bonding
Glycopeptides (N/O-linked)
High Throughput Synthesis
N-Methyl Peptides
Peptide Thioesters
Peptoids
Phospho-peptides
PNA

Liberty Blue HT12 + Razor Cleavage System 

Cleave peptides in only 30 minutes.
The Razor is the perfect compliment to the Liberty PRIME. Cleave peptides in only 30 minutes while protecting your synthesizer from volatile TFA fumes.