RNA molecules play a number of important roles in cells. The processing and regulation of RNA molecules is strictly controlled by RNA-binding proteins (RBPs), which bind to RNA by recognizing sequences and structural motifs and regulate RNA processing by cell type, conditioning specificity, or time. Crosslinking and immunoprecipitation (CLIP) can now be used to capture endogenous direct RNA targets and define the actual interaction sites. CLIP technologies include Photoactivatable Ribonucleoside-Enhanced CLIP-seq (PAR-CLIP-seq), individual-nucleotide resolution CLIP-seq (iCLIP-seq), and enhanced CLIP-seq (eCLIP-seq), and the relationship between these technologies is shown in the figure:
https://www.profacgen.com/eclip-seq.htm
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