Neonatal alloimmune thrombocytopenia results from the placental transfer of maternal platelet IgG antibodies (alloantibodies) formed against incompatible fetal platelet antigens. For example, HPA-1a (PLA-A1; Zw) negative mothers carrying an HPA-1a positive fetus develop the anti-HPA-1a antibodies that are found in 80% of neonatal alloimmune thrombocytopenia cases. Additional platelet antigens involved include HPA-5 (Br; Zv) (10% of cases), HPA-2 (Ko), HPA-3 (Bak; Lek), HPA-4 (Pen; Yuk), and HPA-6 (Ca; Tu). Involvement of HLA class I antibodies has been suspected in a few cases, but is not yet proven.
Rat Platelet antibody IgG (PA-IgG) ELISA Kit employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to PA-IgG. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated PA-IgG and incubated. The competitive inhibition reaction is launched between with HRP labeled PA-IgG and unlabeled PA-IgG with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of PA-IgG in the sample. The color development is stopped and the intensity of the color is measured.
Rat Platelet antibody IgG (PA-IgG) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/rat-platelet-antibody-igg-pa-igg-elisa-kit-kte100957/
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