SLC22A12 is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys. Respectively, these altered rates of reabsorption contribute to hyperuricemia and hypouricemia.
Rat Solute carrier family 22 member 12 (SLC22A12) ELISA Kit employs a two-site sandwich ELISA to quantitate SLC22A12 in samples. An antibody specific for SLC22A12 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySLC22A12 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SLC22A12 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SLC22A12 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Rat Solute carrier family 22 member 12 (SLC22A12) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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