Human Dynein heavy chain 11, axonemal (DNAH11) ELISA Kit,Abbkine_specification/price/image

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DNAH11 encodes a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAHC11 belongs to the putative axonemal outer dynein arm DHC group and is homologous to rat DLP11. RT-PCR assays indicated that DNAHC11 is expressed primarily in trachea and testis, 2 tissues containing axonemal structures.

Human Dynein heavy chain 11, axonemal (DNAH11) ELISA Kit employs a two-site sandwich ELISA to quantitate DNAH11 in samples. An antibody specific for DNAH11 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyDNAH11 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for DNAH11 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of DNAH11 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Dynein heavy chain 11, axonemal (DNAH11) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.