Kallikrein 6, also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikrein 6 was originally described from the brain as an enzyme involved in degradation of amyloid plaque protein (APP) and hK6 was thought to be a beta secretase.Kallikrein 6 was shown to be elevated in the sera patients with Alzheimer’s disease and Parkinson’s disease and in animal models of multiple sclerosis. The neuronal protein alpha-synuclein was shown to be cleaved by hK6, as has APP and hK6 has been implicated in vascular morphogenesis and angiogenesis. MSP has also been shown to rapidly degrade myelin-specific protein, laminin and fibronectin.
Human Kallikrein 6 (KLK 6) ELISA Kit employs a two-site sandwich ELISA to quantitate KLK6 in samples. An antibody specific for KLK6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyKLK6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KLK6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KLK6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Kallikrein 6 (KLK 6) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/human-kallikrein-6-klk-6-elisa-kit-kte61895/
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