Human Phosphatidate phosphatase LPIN1 (LPIN1) ELISA Kit,Abbkine_specification/price/image

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Lipin-1 has phosphatidate phosphatase activity.This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.Database analysis identified the human LPIN1 gene, as well as the human and mouse LPIN2 and LPIN3 genes. Consistent with the observed reduction of adipose tissue mass in fld mice, wildtype Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of 3T3-L2 preadipocytes. The results indicated that lipin is required for normal adipose tissue development, and provided a candidate gene for human lipodystrophy.

Human Phosphatidate phosphatase LPIN1 (LPIN1) ELISA Kit employs a two-site sandwich ELISA to quantitate LPIN1 in samples. An antibody specific for LPIN1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLPIN1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LPIN1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LPIN1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Phosphatidate phosphatase LPIN1 (LPIN1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/human-phosphatidate-phosphatase-lpin1-lpin1-elisa-kit-kte61788/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.