Homo Sapiens Screening Array-V1 85K (HSSA-V1)

China's First Human Genotyping Microarray with Full Autonomous Intellectual Property Rights.

(Including SNP Markers, beadchips, reagent kits and microarray scanners.)

Introduction：

Homo Sapiens Screening Array-V1 85K array features 79,212 SNP markers, which can be expanded to 85K. These markers distribute across chromosomes 1 through 22 and the X chromosome.，and implicated in Pharmacogenomics, Disease Susceptibility, and the diversification of Genetic Information.

They encompass a broad range of targets integral to ancestry analysis, genetic traits, mental health, dietary nutrition, skin characteristics, sports health, as well as genetic variation screening for disease predispositions. This array serves as a powerful tool to facilitate in-depth investigations into human genetic information and its implications.

Pharmacogenomics：

The selected pharmacogenomic SNP markers are identified that are associated with drug absorption, distribution, metabolism, and excretion( ADME ) based on the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC), supporting genomic research on various drugs, including. common neuropsychiatric drugs, digestive system medications, cardiovascular agents, anti-infectives, as well as anti-inflammatory and anti-rheumatic drugs.

Disease Susceptibility：

The selected disease susceptibility SNP markers , based on the NHGRI-EBI GWAS (National Human Genome Research Institute-European Bioinformatics Institute Genome-Wide Association Studies),are associated with oncological conditions, cardiovascular and cerebrovascular diseases, neurological psychiatric disorders, as well as digestive system diseases, based on the NHGRI-EBI GWAS (National Human Genome Research Institute-European Bioinformatics Institute Genome-Wide Association Studies).

Diversified genetic information：ancestry analysis, inherited traits, mental health, dietary nutrition, skin characteristics, sports health, etc

Features：

Extending support：

• Allow users to add new SNP markers to existing panels when it is needed

High-Efficiency：

• Rapid delivery time for custom arrays: about 6-8 weeks after design confirmation.
• Fast turnaround time: within 72h per experiment.

High-Throughput：

• From 5K up to 1000K markers per array.

High-Accuracy：

• Each marker is assayed 15-30 times.
• Average call rate ≥ 99.0%, reproducibility ≥99.5%.

USE CASE

Beginning in June 2023, Genebox began using LASO Homo Sapiens Screening Array-V1 85K for personal genetic testing. As of now, over 38,000 samples have undergone testing with HSSA-V1 array, with excellent detection performance: the average call rate is as high as 97.9%, and the average reproducibility is as high as 99.9%.