Shimadzu Introduced New Shim-Pack Bio Diol & IEX Columns

Shimadzu's New Shim-Pack Bio Diol & IEX Columns Improve Characterization Accuracy of Biopharmaceuticals

 

Shimadzu Scientific Instruments (SSI) announces the release of the new Shim-pack Bio Diol & IEX columns that improve the accuracy of the characterization of peptides, oligonucleotide and other biopharmaceuticals.

 

Shim-pack Bio Diol LC columns have different pore sizes, making them effective for analysis of aggregates and fragments of mAb, oligonucleotides and carbohydrates. These columns can reduce particle size from 5μm to 2μm to greatly improve the resolution between aggregates and monomers. Users can also reduce the column length from 300mm to 150mm using a 2μm particle to achieve a 50% less run time, while maintaining resolution.

 

Shim-pack Bio IEX Ion Exchange Columns are available in Q (quaternary ammonium) and SP (sulfopropyl) chemistries and are based on porous (Q and SP columns) and non-porous (Q-NP and SP-NP columns) hydrophilic polymers with low nonspecific adsorption. The porous particles offer excellent binding capacity with exceptionally high efficiency, and the non-porous particles offer high efficiency and exceptional resolution.

 

Shim-pack Bio Diol & IEX Columns

Solutions for the analysis of peptides, oligonucleotides, and biopharmaceuticals

The accurate analysis of biopharmaceutical compounds is needed when developing high quality pharmaceuticals. Shim-pack Bio Diol and IEX columns will improve the accuracy of the characterization of peptides, oligonucleotide and other biopharmaceuticals.

 

Shim-pack Bio Diol – Size Exclusion Columns

With different pore sizes, Shim-pack Bio Diol LC columns are effective for analysis of aggregates and fragments of mAb, oligonucleotides and carbohydrates. By reducing the particle size from 5μm to 2μm, the resolution between aggregates and monomers was greatly improved. Furthermore, by reducing the column length from 300mm to 150mm using a 2μm particle, 50% less run time was achieved, while maintaining resolution as compared to the original method that used a 5μm, 4.6 × 300mm column.

 

Get better resolution in half the time!

Shim-pack Bio Diol	Diol-60	Diol-120	Diol-200	Diol-300
Particle	Silica
Ligand	Dihydroxypropyl(Diol)
Particle Size	3μm, 5 μm		2 μm, 3 μm, 5 μm
Pore Size	6 nm	12 nm	20 nm	30 nm
pH Range	5.0 - 7.5
Molecular Weight Range	below 10,000	1,000 - 100,000	5,000 - 300,000	20,000 - 1,000,000

 

 

Shim-pack Bio IEX – Ion Exchange Columns

Shim-pack Bio IEX Columns are available in Q (quaternary ammonium) and SP (sulfopropyl) chemistries and are based on porous (Q and SP columns) and non-porous (Q-NP and SP-NP columns) hydrophilic polymers with low nonspecific adsorption. The porous particles offer excellent binding capacity with exceptionally high efficiency and the non-porous particles offer high efficiency and exceptional resolution.

 

 

Shim-pack Bio IEX	Q-NP	SP-NP	Q	SP
Particle	hydrophilic non-porous polymer		hydrophilic porous polymer
Particle Size	3 μm, 5 μm		5 μm
Ligand	- CH2N+(CH3)3	- (CH2)3SO3-	- CH2N+(CH3)3	- (CH2)3SO3-
pH Range	2 - 12