Postnova Analytics: Technique for Characterising Liposome Formulated Drugs

Postnova Analytics has published an application study that describes a new method for quantification of liposome encapsulated drug using Centrifugal Field-Flow Fractionation (CF3).

Nanoparticles including liposomes are increasingly used for delivery of drug molecules. During formulation of a liposome around a drug particle, a relatively large amount of free drug may remain unencapsulated and therefore not available for drug delivery via the liposomal carrier. For formulation groups adopting this drug delivery methodology it is important to quantify the amount of free versus encapsulated drug in a product in order to accurately determine the delivered dose of drug to a patient. 

In this study, Centrifugal Field-Flow Fractionation coupled with UV-Vis detection was shown to be able to separate and quantify the amount of free drug in a liposome-drug product. The separation data was verified using optical microscopy. The authors conclude that Centrifugal Field-Flow Fractionation shows great promise for separation and quantification of drug particles, as the field of nanomedicine and liposomal drug delivery grows.

The Postnova CF2000 Series system is based on the CF3 principle using a centrifugal field as driving force for the separation. Particles effected by this field are separated by dynamic diffusion based upon both their size and density. This unique feature allows researchers to separate different particle materials having the same particle size. The separation can be further optimized by the use of different eluents and rotation speed programs. The CF2000 has shown great utility for the separation of complex nanoparticle samples in application areas including pharmaceuticals, environmental research, food, cosmetics and agrochemicals.

To download a copy of this study please visit http://www.postnova.com/application-note/view/50.html. For further information on the CF2000 system please contact Postnova Analytics on +49-8191-985-6880 / +44-1885-475007 / +1-801-521-2004 / info@postnova.com. 

Founded in 1997, Postnova Analytics is the inventor and leading international supplier of Field-Flow Fractionation (FFF) systems for markets including biopharmaceuticals, polymers, materials, nanotechnology and environmental sciences. Leveraging its unique and patented modular FFF - Light Scattering Platform, Postnova has been able to provide high performance solutions to a wide range of applications. Today the company's growing product portfolio includes Flow FFF, Centrifugal FFF, Thermal FFF, Size Exclusion Chromatography (SEC), MALS and DLS Light Scattering.  Postnova (www.postnova.com) is located and headquartered in Landsberg am Lech (Germany) and has subsidiaries in the USA, UK and Finland. These offices in conjunction with a highly qualified and trained distribution network provides informed local support to customers worldwide.

Worldwide HQ 

Postnova Analytics GmbH

Max-Planck-Straße 14
86899 Landsberg am Lech

Germany 

 

Tel: +49-8191-985-6880

Email: info@postnova.com 
Web www.postnova.com

UK

 

Postnova Analytics UK Ltd.

Unit 56, The Hop Store

Bishops Frome

WR6 5BT

UK

Tel: +44-1885-475007

Email: info.uk@postnova.com 
Web www.postnova.com

 

North America

Postnova Analytics Inc
230 South 500 East, S. #120
Salt Lake City, Utah 84102
USA

Tel: +1 801 521 2004

Email: info@postnova.com 
Web www.postnova.com