Ecalbio Develop New Quinolones Monoclonal Antibody

Quinolones and fluoroquinolones are chemotherapeutic bactericidal drugs, eradicating bacteria by interfering with DNA replication. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase II enzyme, thereby inhibiting DNA replication and transcription. Recent evidence has shown topoisomerase II is also a target for a variety of quinolone-based drugs. Thus far, most of the compounds that show high activity against the eukaryotic type II enzyme contain aromatic substituents at their C-7 positions.

 

Ecalbio develop new Quinolones monoclonal antibody, which is to identify 21 kinds of drugs, can be used to manufacture ELISA kits and rapid tests, or do immunochromatography.

 

Techology of Quinolones monoclonal antibody is following:

 

Applications:  ELISA , Immunochromatography

Immunogen:  Quinolones- KLH  conjugates
Dilutions: 1:20000 for ELISA
Formation: 2.5 mg /mL, pH=7.4 PBS solution

Species: Mouse

Unit Size: 1 mg

 

Name	Drug identification	IC50（ppb）	Cross-reaction（%）
Total Quinolones	Norfloxacin	0.4	100%
	Ofloxacin	2	20%
	Enrofloxacin	1	40%
	Ciprofloxacin	1	40%
	Flumequine	3	13%
	Danofloxain	1	40%
	Nadifloxacin	0.2	200%
	Enoxacin	0.6	67%
	Lomefloxacin	0.3	133%
	Levofloxacin	0.3	133%
	Pefloxacin	0.15	267%
	Nalidixic acid	0.15	267%
	Picolinic acid	0.2	200%
	Cinoxacin	0.14	286%
	Oxolinic Acid	0.15	267%
	Marbofloxacin	1.5	27%
	Sparfloxacin	3	13%
	Gatifloxacin	5	8%
	Orbifloxacin	1	40%
	Fleroxacin	0.2	200%
	Pazufloxacin	20	2%

 

Storage:

Product is stable for several weeks at 4°C. For extended storage, aliquot content and store product at -20°C. Avoid cycles of freezing and thawing. Expiration date is three years from date of shipping if stored properly.

 

Preservative: Add 0.03% Sodium Azide for long term use.

 

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.