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AMSBIO: Powerful Human iPSC-derived Cells, Kits & Services

Hits:110   Date: 10/9/2020
AMSBIO is launching a new range of human iPSC-derived cells and human iPSC differentiation reagent kits optimized for high-throughput experiments in areas including drug discovery and toxicity screening.

These new products are based upon a novel technology platform that relies on key transcription factor (TF) genes, a combination of which determines the identity of cells. These TFs are so powerful that they can rapidly and efficiently differentiate human iPS cells into specific cell types, such as neurons and skeletal muscle cells. These transcription factors are introduced into cells in a form that does not leave any footprint on the genome.

 
 
Skeletal muscle differentiation using Transcription Factor delivered as RNA

Human induced pluripotent stem cells (iPSCs) are a powerful tool for studying neuronal activity in vitro. Human iPS cells overcome many of the limitations of other popular models, such as immortalized cell lines and primary mouse neurons, which can be plagued by reproducibility issues and lack of biological relevance. Although human iPS cells have many advantages over existing models, one drawback is that differentiation into the desired cell type is a time and labor-intensive process. To address this research bottleneck, AMSBIO is launching a variety of products and services to make research more efficient. This proprietary technology allows for rapid, reproducible differentiation of human iPSC-derived excitatory, GABAergic, dopaminergic and cholinergic neurons without sacrificing purity.
 
The new range also includes a kit to facilitate rapid and efficient differentiation of human iPS or ES cells into skeletal muscle cells in just 7 days. The kit uses a proprietary transcription factor-based stem cell differentiation method to produce a highly pure population of skeletal muscle cells without a genetic footprint. Differentiated cell cultures display typical skeletal muscle morphology and markers, such as myosin heavy chain.

 
 
Excitatory cell cultures expressing neuronal markers and displaying typical neurite outgrowth. Immunofluorescent staining shows expression of the pan-neuronal marker TUBB3 & the glutamatergic neuron-specific marker vGLUT1 on Day 10.
 
To provide you with differentiated stem cells on fast turnaround - AMSBIO is also launching a Stem Cell Differentiation Service to supply highly pure populations without a genetic footprint. Services will begin with a free consultation with one of our experts so that we can tailor services to fit the needs of each project.

For further information please visit https://www.amsbio.com/ipsc-derived-cells-and-differentiation-kits/  or contact AMSBIO on +44-1235-828200 / +1-617-945-5033 / info@amsbio.com
 
Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading transatlantic company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO has in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. This expertise in cell culture and the ECM allows AMSBIO to partner with clients in tailoring cell systems to enhance organoid and spheroid screening outcomes using a variety of 3D culture systems, including organ-on-a-chip microfluidics. For drug discovery research, AMSBIO offers assays, recombinant proteins and cell lines. Drawing upon a huge and comprehensive biorepository, AMSBIO is widely recognised as a leading provider of high-quality tissue specimens (including custom procurement) from both human and animal tissues. The company provides unique clinical grade products for stem cell and cell therapy applications these include high quality solutions for viral delivery (lentivirus, adenovirus and adeno-associated virus) in addition to GMP cryopreservation technology.

 
AMSBIO
Tel:+44 (0) 1235 828 200
E-mail:info@amsbio.com
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