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Postnova Analytics: White Paper Demonstrates Benefits of Electrical Asymmetrical Field Flow Fractionation

Hits:345   Date: 1/22/2020

An informative white paper from Postnova Analytics demonstrates how its novel Electrical and Asymmetrical Field Flow Fractionation (EAF4) technology can be used to separate a wide variety of nano-sized materials while simultaneously determining surface charge.

Drawing upon this proprietary technology, the Postnova Analytics EAF2000 is the only field-proven system that combines the principle of Electrical and Asymmetrical Field Flow Fractionation in a single platform. In an EAF2000 system, Electrical and Cross Flow Fields are applied together across the FFF channel enabling separation by size and simultaneous measurement of particle charge based on electrophoretic mobility. Combining these two powerful separation techniques in a single platform opens the door to characterizing complex samples that have proven impossible using other techniques.


A: EAF2000 system

With installed systems in leading academic and government research institutions as well as major pharmaceutical laboratories in Asia, Europe and North America - Postnova Analytics' pioneering EAF2000 system is proven to separate and characterize complex proteins, antibodies and viruses as well as charged nanoparticles, colloids and polymers.

While traditional Flow Field Flow Fractionation instruments are well known to provide particle size or molar mass distribution data, using an EAF2000 system allows identifying charge heterogeneities which might be present inside the different size and molar mass fractions. As particle or molecule charge plays a large role in many applications, including protein aggregation, polymer flocculation, and particle agglomeration, the EAF2000 opens completely new ways for a significantly better understanding of these phenomena and will quickly help to establish more efficient product development and QC processes.


Separation of a two-particle polystyrene mixture and determination of their electrophoretic mobility

For a copy of the white paper please visit or contact Postnova Analytics on +49-8191-985-6880 / +44-1885-475007 / +1-801-521-2004 or 

Founded in 1997, Postnova Analytics is the inventor and leading international supplier of Field-Flow Fractionation (FFF) systems for markets including biopharmaceuticals, polymers, materials, nanotechnology and environmental sciences. Leveraging its unique and patented modular FFF - Light Scattering Platform, Postnova has been able to provide high performance solutions to a wide range of applications. Today the company's growing product portfolio also includes Flow FFF, Centrifugal FFF, Thermal FFF, Size Exclusion Chromatography (SEC), MALS and DLS.  Postnova ( is located and headquartered in Landsberg am Lech (Germany) and has subsidiaries in the USA, UK and Finland. These offices, in conjunction with a highly qualified and trained distribution network, provide informed local support to customers worldwide.


Worldwide HQ 

Postnova Analytics GmbH

Max-Planck-Straße 14
86899 Landsberg am Lech

Tel: +49-8191-985-6880

Postnova Analytics GmbH
Tel:+49 8191 985 688-0