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AMSBIO Expands Wnt Signaling Pathway Product Portfolio

hits:209     Date:12/12/18
AMSBIO has expanded its range of Wingless/Integrated (Wnt) recombinant proteins, stable reporter cell lines, antibodies and ELISA kits to assist researchers in the fields of developmental biology and oncology.

The Wnt family of cysteine-rich secreted polypeptides comprise more than 16 mammalian family members involved in several important cell functions such as cell cell-cell communication, proliferation, migration, polarity, survival and self-renewal. In addition, the Wnt3a signal plays an important role in the ability of organoids to expand. Additionally, loss of activation of Wnt expression is associated with alteration of cell fate, morphogenesis and mitogenesis. 

AMSBIO offers a comprehensive range of Wnt human and mouse recombinant proteins in high (85 鈥 90%) and low (75%) purity. These human recombinant proteins are purified from HEK293 cells while the mouse proteins are expressed in CHO cells. Both are highly suitable for various cell-based assays and treatments. Recombinant Wnt proteins are now also available with a new Wnt stabilizer that can significantly extend the activity of this protein, extending half-life of Wnt3a in serum-free medium to about 24-30 hours (in contrast to half-life of around 2 hours without stabilizer).

High purity HEK293, HCT-116 or SW480 Wnt reporter cell lines are available from AMSBIO all of which have matching controls and can also be ordered as a package in pairs. These stable cell lines have shown particular utility in applications including evaluation of Wnt protein bioactivity or stability and screening of anti-Wnt compounds, antibodies, signal enhancers and to monitor the activity of ß-catenin-based Wnt signal transduction pathway. 

For detection of several different Wnt proteins, AMSBIO offers several sensitive and easy-to-use human and mouse ELISA assay kits. AMSBIO also offers a range of polyclonal Wnt antibodies produced in-vivo, suitable for ELISA, IHC and Lateral Flow applications.

To investigate AMSBIO's one-stop shop for top quality products for  Wnt signaling research please visit www.amsbio.com/wnt-signaling-cancer-proteins.aspx or contact the company now on +44-1235-828200/ +1-617-945-5033 or info@amsbio.com.

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO is able to draw upon in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. Widely acknowledged as an expert in cell culture, AMSBIO partners with clients in tailoring cell systems to enhance organoid and spheroid type screening outcomes from a technological and cost-effective perspective.

Worldwide HQ 

AMS Biotechnology (AMSBIO)
184 Milton Park
Abingdon
Oxon OX14 4SE
UK
Tel: +44-1235-828200
Fax: +44-1235-820482
Email: info@amsbio.com 
Web www.amsbio.com
 
North American HQ
 
AMSBIO LLC
1035 Cambridge Street
Cambridge
MA 02141
USA
Tel: +1.617.945.5033 
Tel: +1.800.987.0985 (toll free)
Email: info@amsbio.com 
Web www.amsbio.com
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