The important physiological and pharmacological functions of proteins require the participation of small drug molecules. Small drug molecules can promote or inhibit the realization of protein functions through interaction with proteins, especially the combination of drugs with plasma proteins will affect the biological activity of drugs. Drugs bind to plasma proteins to varying degrees in the plasma, and the degree of binding can affect the absorption, distribution, metabolism, and excretion of the drug in the body, and then affect the pharmacodynamic behavior of the drug.  Therefore, the determination of drug plasma protein binding rate is important for drug development.

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