ATTEC (autophagosome-tethering compounds) is a novel target protein degrade strategy that based on the macroautophagy/autophagy pathway. In eukaryotic cells, macroautophagy/autophagy is a bulk degradation system that engulfs proteins into phagophores and induces subsequent autophagic degradation process. Without involving complicated enzymatic reactions, ATTEC has attracted scientist’s attention on diseases related proteins degradation and drug discovery.

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